Genetically
engineered
human insulin
cancer
genetically
engineered
viruses
diabetes
antipsychotic
drugs
schizophrenia

The person who utilize the progression principle will keep adding the difficulty of the exercise that he's doing, while the person who does not, will only stay stagnant.  the person that utilize progression principle, will get a stronger endurance because now his body is conditioned to do harsher routines.{the answer was already on verified)

Lightning would be your answer

Answera tightly sealed house with an unvented water heater;