Why did many Americans oppose the Indian Removal Act?

The Indian Removal Act was signed into law on May 28, 1830, by United States President Andrew Jackson. The law authorized the president to negotiate with southern Native American tribes for their removal to federal territory west of the Mississippi River in exchange for white settlement of their ancestral lands.[1][2][3] The act has been referred to as a unitary act of systematic genocide, because it discriminated against an ethnic group in so far as to make certain the death of vast numbers of its population.[4] The Act was signed by Andrew Jackson and it was strongly enforced under his administration and that of Martin Van Buren, which extended until 1841.[5]

Explanation:

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some american cities felt workers were being oppressed by business monopolies