What was the most significant impact of European exploration on native populations in the New World? A) the destruction of entire civilizations as a result of disease and warfare

B) the mixing of Native American and European blood (gene pool) and customs

C) changes in the way Native Americans worshiped and sought spiritual guidance

D) changes to Native American culture, such as clothing, food and social norms

A) the destruction of entire civilizations as a result of disease and warfare

Explanation:

The impact of European exploration on native populations was the introduction of diseases into the communities. These diseases were brought in through microbes on the European explorers and caused havoc because the native communities didn’t have immunity against the diseases unlike the explorers.

There were also various degrees of warfare due to the native communities wanting liberation and better standards of living later on.

i'm pretty sure it would be, the mediterranean sea.