What was one reason Native American Indians in the Southeast were removed from their native lands?

The expansion of Anglo-American settlement into the Trans-Appalachian west led to the passage of the Indian Removal Act in 1830, forcing all eastern tribes to move to new homelands west of the Mississippi River in the Indian Territory. ... Texas, too, forced out all remaining tribes in 1859.

Explanation:

The Removal Act paved the way for the forced expulsion of tens of thousands of American Indians from their land into the West in an event widely known as the "Trail of Tears," a forced resettlement of the Indian population.

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