Find slope of (-3,-1) (2,-3) using slope formula

I'm confused on this could anyone me and show me what i need to do to solve it.

Which of the following is the major negative aspect of crossover designs for research studies? a. prohibitive cost b. residual effects c-subject drepout d. incomplete randomization e. large sample size required

Type the next three numbers in a sequence 80, 90, 85, 95, 90, 100, 95, 105